On March 5, Professor Christopher Hollot, the head of the Electrical and Computer Engineering Department at UMass Amherst, delivered a talk for the Boston University Electrical and Computer Engineering Department Distinguished Lecture Series. The series is billed as “a forum for eminent individuals from the worlds of academia and industry to share their experience and vision in various areas of electrical and computer engineering.” Designed to cover a breadth of topics, the lectures target both undergraduate and graduate students as well as faculty. Hollot’s lecture was entitled “Regulation of Cell Populations in Individuals Using Feedback-Based Drug-Dosing Protocols.”
According to Hollot’s abstract, “This talk is concerned with the regulation of cell populations in individuals using feedback-based drug-dosing protocols. Cell populations can be affected by drugs that induce formation of cell-types as well as by inherent cell lifespans. Cell populations can be modeled by compartmental models involving cell lifespan distributions, and these distributions vary across individuals. A challenge arises in designing a single feedback-based drug-dosing protocol to regulate cell populations that is robust to this cell lifespan uncertainty. A motivating application is the use of artificial erythropoietin (EPO) as a drug to regulate red blood cells and anemia in individuals with chronic kidney disease."
Hollot joined the ECE department at UMass Amherst in 1988 and has been its department head since 2006. His research interests are in the theory and application of feedback control, and he is the co-director of the Control in Biomedical Systems Research Lab, whose mission is to develop feedback control methods and tools for biomedical applications.
Among many other honors, Hollot was chosen as an IEEE Fellow in 2004. He received an NSF Presidential Young Investigator Award in 1988. In addition, Hollot received the Ben Dasher Award for Best Paper at the 2009 Frontiers in Education Conference. He was a nominee for the UMass Amherst Distinguished Teaching Award in 1987, 2003, 2004, and 2005. He was also the recipient of the College of Engineering Outstanding Senior Faculty Award in 2004 and the ECE Outstanding Faculty Teaching Award in 1987, 1998, 2001, 2002, and 2004.
Hollot received his Ph.D. in electrical engineering from the University of Rochester in 1984 after earning his B.S. at West Virginia University in 1974 and M.S. at Syracuse University in 1980. (March 2014)